From 1994 to 2003, he worked at various levels in the health system in Rwanda, including managing the national immunization program.
In January 2004 for a period of six months, he was the Permanent Secretary of the country coordinating mechanisms of the GFATM in Rwanda and has also worked in the past for WHO and UNICEF and as an independent consultant for WHO, UNICEF, USAID, and the GFATM.
Dr. Mihigo is currently Regional Advisor in the Immunization, Vaccines Development program at the WHO Regional Office for Africa (AFRO) in Brazzaville, Congo.